Monthly Archives: June 2013

Approach to papillary lesions of the breast

The terminology can be confusing. I’ll try to add pictures/diagrams to clarify at a later date. Feel free to ask questions. Intraductal papilloma – duct structures with broad fibrovascular cores lined by an myoepithelial and epithelial lining. May be solitary … Continue reading

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Benign Sclerosing Lesions of the Breast

The 3 entities are sclerosing adenosis, radial scar (complex sclerosing lesion) and microglandular adenosis. Sclerosis adenosis: A lobulocentric lesion (arise in association with the terminal duct lobular unit) with distorted obliterated glands with a myoepithelial layer in a fibrotic or … Continue reading

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Approach to testicular tumors

Classified as Germ cell tumors & Non germ cell tumours – 90% are germ cell tumors. Consider the serum marker levels HCG, AFP. Germ cell tumours are seminomatous and non seminomatous. Age is important when considering the differential. As a … Continue reading

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Soft tissue tumours with a myxoid appearance

Myxoid liposarcoma: Myxoid background Chicken wire like curvilinear blood vessels Lipoblasts Mucin pools When >5% round cell component- Myxoid round cell liposarcoma, t(12;16)(q13;p11) karyotype leading to fusion of DDIT3 (CHOP) with FUS (TLS). S100 positive younger patients Low grade fibromyxoid … Continue reading

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Endometrial Hyperplasia

Simple Hyperplasia Normal to slightly increased gland to stromal ratio Proliferative endometrium Cystically dilated glands of variabe sizes (diffuse compared to a few in disordered proliferative endometrium) Oval nuclei maintaining orientation to basement membrane *simple hyperplasia is due to unopposed/prolonged … Continue reading

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Breast Pathology: Ductal carcinoma in situ

Is a clonal non invasive proliferation in breast involving ducts (although may involve lobules termed cancerization). A precursor of invasive ca. Most commonly seen as microcalcifications – rod shaped, branching in high grade and granular in low grade. Tx WLE … Continue reading

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Breast Pathology: Intraductal epithelial proliferations

Usual type epithelial hyperplasia: Peripheral slit like spaces Streaming Mixed population Uneven distribution and overlapping of nuclei Variation in appearances including oval nuclei mosaic pattern of staining with Ck5, Ck14 and ER pos punctate necrosis and ocasional nonatypical mitoses may … Continue reading

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