Poorly Differentiated Carcinoma of the Colon

The differential diagnosis of poorly differentiated carcinoma of the colon include:

  • Poorly differentiated adenocarcinoma
  • Medullary carcinoma of the colon &
  • Large cell neuroendocrine carcinoma

Medullary carcinoma will usually have sheets, nest or trabecular of small to medium sized cells with a pushing border and a lymphocytic infiltrate with Crohn’s like lymphoid aggregates at the tumour edge. Negative for neuroendocrine markers. Associated with microsatellite instability.

Poorly differentiated adenocarcinoma may show areas with glands.

Neuroendocrine carcinoma – positivity to CD56, synaptophysin & chromogranin.

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