Monthly Archives: October 2012

Benign lesions of the Endocervix

Microglandular hyperplasia – Although the architecture may be appear complex there is little atypia compared to high grade CGIN. The stratified appearance is due to basal cell hyperplasia. Mucinous glands are present on the luminal surface. Differential diagnoses include clear … Continue reading

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Case Report 1: Adenosarcoma of the Uterus

Today I looked at a TAH & BSO for Adenosarcoma which was identified on biopsy of a polyp in the uterus. Adenosarcoma is an entity which falls into the mixed mullerian tumour category with benign glands and sarcomatous stroma (which … Continue reading

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Approach to Basaloid Neoplasms of the Skin

I was caught out today by a particularly large relatively well circumscribed basaloid neoplasm of the dermis for which my first thought was that it was likely to be an adnexal tumour. However basal cell carcinoma should always be a … Continue reading

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Approach to Granulomatous Inflammation

Once it is identified that granulomas present – epitheloid histiocytes and giant cells. (It may be helpful to identify the type of giant cells*). Assess whether there is necrosis and if so evidence of caseation. Are there neutrophils present to … Continue reading

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Nasal Tumour

Today I looked at a case of an exophytic, papillomatous nasal tumour with hyperplastic squamous epithelium which was cytologically really very bland. It was a exophytic Schneiderian papilloma which is common in the nose where there is not much opportunity for … Continue reading

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Polarised light microscopy for Crystal Arthropathies

Slide Preparation: Should have a wet preparation (where the fluid is mounted as received) and a fixed H&E preparation. Using Polarisers: Variable depending on make of microscope. 2 polarisers are required. Insert first polariser. Then place second polariser and rotate … Continue reading

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Polyps of the Small & Large Intestine

Colonic Polyps may be Inflammatory, Hamartomatous, Hyperplastic, or Neoplastic Neoplastic Tubular Adenomas – with low grade/high grade dysplasia/?Invasive focus. Tubular, Tubular Villous or Villous Adenomas. Characterised by hyperchromasia, elongation & stratification. Serrated lesions – Sessile serrated polyp/ Sessile serrated adenoma. Typically in … Continue reading

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